GUIDE

Poison Guide

Updated: 2026-04-23

Poison Guide

Note: This page explains the community debate around Poison. It’s not an official tier list.

What is Poison?

Poison is a dice type that deals damage over time (DOT). It’s passive damage that doesn’t require active dice rolls.

That makes Poison attractive in longer fights, because damage can keep building while you focus on surviving and maintaining the run. The tradeoff is that Poison can feel slow when enemies need to die quickly.

Community Debate

There has been significant community discussion about Poison:

Arguments FOR Poison

  • “Poison stacks for each dice once upgraded”
  • “High damage in long fights”
  • “Acorn Miasma + Does Not Enter Play has synergy”

Arguments AGAINST (or cautious)

  • “Ramp-up is slow”
  • “Weak against short encounters”
  • “Can’t remove from pool once in”

Key Upgrades

Must-Have for Poison

  • Does Not Enter Play - Keeps poison dice active
  • Poison Stacks - Increases DOT damage

When to Consider Poison

Poison makes more sense when:

  • The fight lasts long enough for damage over time to matter
  • You already see upgrades that support stacking or keeping poison active
  • Your current route needs passive damage instead of immediate burst

Be careful if the stage is short, time-sensitive, or built around enemies that need fast burst damage. In those cases, Poison may underperform even if it looks strong on paper.

Verdict

Community consensus:

  • Poison is viable in long fights where it can stack up
  • Not ideal for short burst encounters
  • Works best with specific upgrade synergies

Disclaimer: This is community experience, not verified fact. Game balance changes may affect viability.